Boc-(S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid is an organic compound with the following properties:
1. Appearance: colorless solid.
2. molecular formula: C. H. FNO.
3. Molecular weight: 313.33g/mol.
4. Solubility: Soluble in some polar organic solvents, such as dimethylformamide (DMF) and dichloromethane.
5. Melting point: between about 92-94°C.
Boc-(S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid is widely used in organic synthesis and medicinal chemistry. Its main uses include:
1. drug intermediates: as intermediates in drug synthesis, used for the synthesis of biologically active compounds, such as anticancer drugs, hormone drugs.
2. peptide synthesis: as an amino acid protecting group, used in peptide synthesis reaction, functional groups on amino acid side chains, such as carboxyl and amino groups, can be protected to prevent non-specific reactions.
the common method for preparing Boc-(S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid is to first react amino-acrylate and 3-fluorobenzaldehyde to obtain the corresponding alcohol, and then react with Boc-ethyl imidate in the presence of sodium bicarbonate to obtain the target product.
For safety information, the specific safety evaluation of Boc-(S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid may require further experimental data and expertise. In use, need to pay attention to the following matters:
1. storage: should be stored in a dry, cool place, avoid direct sunlight.
2. operation: operation should wear appropriate personal protective equipment, such as gloves, protective glasses, etc.
3. waste disposal: in accordance with local environmental regulations, properly dispose of waste to avoid environmental pollution.
When using and handling this compound, it is recommended to follow laboratory safety procedures and consult a professional.